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2012 1
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XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.
Hong R, Tan Y, Tian X, Huang Z, Wang J, Ni H, Yang J, Bu W, Yang S, Li T, Yu F, Zhong W, Sun T, Wang X, Li D, Liu M, Yang Y, Zhou J. Hong R, et al. EMBO Rep. 2024 Mar;25(3):1055-1074. doi: 10.1038/s44319-024-00092-y. Epub 2024 Feb 13. EMBO Rep. 2024. PMID: 38351372 Free PMC article.
Mechanistic studies show that the X-linked inhibitor of apoptosis (XIAP) functions as an E3 ubiquitin ligase for IFT88. Transforming growth factor-beta (TGF-beta), a profibrotic factor, enhances XIAP-mediated ubiquitination of IFT88, promoting its proteasomal degrad …
Mechanistic studies show that the X-linked inhibitor of apoptosis (XIAP) functions as an E3 ubiquitin ligase for IFT88. Transforming …
YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression.
Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N, Knight MM. Meng H, et al. Osteoarthritis Cartilage. 2023 May;31(5):600-612. doi: 10.1016/j.joca.2022.11.001. Epub 2022 Nov 8. Osteoarthritis Cartilage. 2023. PMID: 36368426 Free article.
OBJECTIVE: To clarify the role of YAP in modulating cartilage inflammation and degradation and the involvement of primary cilia and associated intraflagellar transport (IFT). ...Mechanical properties of cartilage explants were tested to confirm cartilage degradation. The i …
OBJECTIVE: To clarify the role of YAP in modulating cartilage inflammation and degradation and the involvement of primary cilia and a …
Primary cilia-mediated regulation of microglial secretion in Alzheimer's disease.
Yeo S, Jang J, Jung HJ, Lee H, Choe Y. Yeo S, et al. Front Mol Biosci. 2023 Oct 23;10:1250335. doi: 10.3389/fmolb.2023.1250335. eCollection 2023. Front Mol Biosci. 2023. PMID: 37942288 Free PMC article.
In affected neurons, incomplete clearance of toxic proteins by neighboring microglia leads to irreversible brain inflammation, for which cellular signaling is poorly understood. Through single-cell transcriptomic analysis, we discovered distinct regional differences in the …
In affected neurons, incomplete clearance of toxic proteins by neighboring microglia leads to irreversible brain inflammation, for wh …
Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis.
Rizaldy D, Toriyama M, Kato H, Fukui R, Fujita F, Nakamura M, Okada F, Morita A, Ishii KJ. Rizaldy D, et al. Exp Dermatol. 2021 Jun;30(6):792-803. doi: 10.1111/exd.14285. Epub 2021 Feb 12. Exp Dermatol. 2021. PMID: 33455013
The objectives of this study is to elucidate the incidence of primary cilia in skin inflammation and the potential mechanism underlying the dysregulation of keratinocytes. ...An increase of ciliated cells in the epidermis may impair keratinocyte differentiation under stres …
The objectives of this study is to elucidate the incidence of primary cilia in skin inflammation and the potential mechanism underlyi …
Integrin-β1 is required for the renal cystogenesis caused by ciliary defects.
Yoo M, Barisoni LMC, Lee K, Gusella GL. Yoo M, et al. Am J Physiol Renal Physiol. 2020 May 1;318(5):F1306-F1312. doi: 10.1152/ajprenal.00070.2020. Epub 2020 Apr 20. Am J Physiol Renal Physiol. 2020. PMID: 32308017 Free PMC article.
We addressed this question by investigating the effect of integrin-beta(1) deletion in a ciliopathy genetic model in which the Ift88 gene, a component of complex B of intraflagellar transport that is required for the proper assembly of cilia, is specifically ablated in pri …
We addressed this question by investigating the effect of integrin-beta(1) deletion in a ciliopathy genetic model in which the Ift88 …
Carbon black nanoparticles induce HDAC6-mediated inflammatory responses in 16HBE cells.
Lin H, Fu G, Yu Q, Wang Z, Zuo Y, Shi Y, Zhang L, Gu Y, Qin L, Zhou T. Lin H, et al. Toxicol Ind Health. 2020 Oct;36(10):759-768. doi: 10.1177/0748233720947214. Epub 2020 Aug 12. Toxicol Ind Health. 2020. PMID: 32783763
Intracellular HDAC6 and intraflagellar transport protein 88 (IFT88) mRNA and protein were determined by real-time polymerase chain reaction and Western blot, respectively. ...Downregulation of the HDAC6 gene inhibits CBNPs-induced inflammatory responses in bronchial epithe …
Intracellular HDAC6 and intraflagellar transport protein 88 (IFT88) mRNA and protein were determined by real-time polymerase chain re …
Naringenin attenuated airway cilia structural and functional injury induced by cigarette smoke extract via IL-17 and cAMP pathways.
Zhang J, Fan W, Wu H, Yao Y, Jin L, Chen R, Xu Z, Su W, Wang Y, Li P. Zhang J, et al. Phytomedicine. 2024 Apr;126:155053. doi: 10.1016/j.phymed.2023.155053. Epub 2023 Sep 2. Phytomedicine. 2024. PMID: 38359483
RESULTS: The targets of ciliary diseases regulated by naringenin were significantly enriched in inflammation and oxidative stress pathways. Also, the CSE decreased the number of cilia in the tracheal rings and ALI cultures and reduced the ciliary beat frequency (CBF). Howe …
RESULTS: The targets of ciliary diseases regulated by naringenin were significantly enriched in inflammation and oxidative stress pat …
Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways.
Gilley SK, Stenbit AE, Pasek RC, Sas KM, Steele SL, Amria M, Bunni MA, Estell KP, Schwiebert LM, Flume P, Gooz M, Haycraft CJ, Yoder BK, Miller C, Pavlik JA, Turner GA, Sisson JH, Bell PD. Gilley SK, et al. Am J Physiol Lung Cell Mol Physiol. 2014 Jan;306(2):L162-9. doi: 10.1152/ajplung.00095.2013. Epub 2013 Nov 8. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24213915 Free PMC article.
Airway cilia were deleted by knockout of IFT88, and airway remodeling and pulmonary function were evaluated. In IFT88(-) mice there was a substantial loss of airway cilia on respiratory epithelium. ...
Airway cilia were deleted by knockout of IFT88, and airway remodeling and pulmonary function were evaluated. In IFT88(-) mice …
Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.
Mc Fie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AKT. Mc Fie M, et al. J Cell Sci. 2020 Jul 8;133(13):jcs239871. doi: 10.1242/jcs.239871. J Cell Sci. 2020. PMID: 32503942 Free PMC article.
Our previous research revealed that disruption of ciliary intraflagellar transport (IFT), altered the cell response to IL-1beta, supporting a putative link emerging between cilia and inflammation. Here, we show that IFT88 depletion affects specific cytokine-regulate …
Our previous research revealed that disruption of ciliary intraflagellar transport (IFT), altered the cell response to IL-1beta, supporting …
18 results